منابع مشابه
Viral latency in HIV disease
The term "latency" is often applied to infections caused by herpesviruses, wherein viral replication and disease manifestations appear concordantly after long intervals of silence. In the case of the human immunodeficiency virus (HIV), an asymptomatic period of "clinical latency" can intervene between infection and the development of the acquired immune deficiency syndrome (AIDS). Freedom from ...
متن کاملLatency and viral persistence in HIV-1 infection.
HIV-1 infection can be controlled with combinations of antiretroviral drugs, an approach known as highly active antiretroviral therapy (HAART). In patients who respond well to HAART, viremia decreases to below the limits of detection, disease progression stops, and reconstitution of the immune system begins. For the first time since the beginning of the epidemic, the possibility of curing HIV-1...
متن کاملAn Evolutionary Role for HIV Latency in Enhancing Viral Transmission
HIV latency is the chief obstacle to eradicating HIV but is widely believed to be an evolutionary accident providing no lentiviral fitness advantage. However, findings of latency being "hardwired" into HIV's gene-regulatory circuitry appear inconsistent with latency being an evolutionary accident, given HIV's rapid mutation rate. Here, we propose that latency is an evolutionary "bet-hedging" st...
متن کاملHuman Immunodeficiency Virus (HIV)-1 Integration Sites in Viral Latency
The persistence of human immunodeficiency virus type 1 (HIV-1) in latent reservoirs is a major barrier to HIV cure. Reservoir establishment depends on low viral expression that may be related to provirus integration sites (IS). In vitro, in cell lines and primary T cells, latency is associated with specific IS through reduced viral expression mediated by transcriptional interference by host cel...
متن کاملHIV latency.
HIV-1 can establish a state of latent infection at the level of individual T cells. Latently infected cells are rare in vivo and appear to arise when activated CD4(+) T cells, the major targets cells for HIV-1, become infected and survive long enough to revert back to a resting memory state, which is nonpermissive for viral gene expression. Because latent virus resides in memory T cells, it per...
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ژورنال
عنوان ژورنال: Cell
سال: 1995
ISSN: 0092-8674
DOI: 10.1016/0092-8674(95)90305-4